Beppe de Tomasi was born in Milan and received a degree in Pharmacy from the University of Pavia. Subsequently he enrolled in the Acting Academy in Milan, where he received his diploma and recognition as being the best student, as well as being awarded with the "Salvini" Prize. He also studied singing and was one of the finalists of the Verdi Competition in Parma.
Following a brief career as a singer and actor, he became assistant to Attilio Colonnello and Mauro Bolognini. In 1967, he made his debut as director at the Teatro Sociale in Como with Madama Butterfly and since then, he has worked in all of the well-known theatres and in all of the Italian Autonomous Organizations, (now Foundations), excluding La Scala in Milan.
He worked at the Chicago Opera and the opera houses in San Francisco, Philadelphia, Baltimore and Washington, among others. In 1996, he made his debut at the Metropolitan in New York in Fedora by Giordano, which was a great success. He has also worked at the Teatro Colòn in Buenos Aires, in Santiago Chile, Tokyo, Seoul, Salzburg, Bregenz, Brussels, Montpellier, Monte Carlo, Munich, Lisbon, Athens, Istanbul, Dordrecht and many others.
In Spain, he is one of the best known directors, having been present almost every year for the opera season at the Teatro Liceu in Barcelona, Teatro Real in Madrid and at the festivals in Oviedo, Bilbao and Santander. He also inaugurated the Teatro della Maestranza in Seville.
In 1970, he was awarded with the "Noce D'Oro" and, in 1987, with the "Illica" Prize for the best Italian Director.
He has staged more than 120 Italian and foreign Opera titles, making a total of approximately 700 opera performances. As well as this, he is also involved in stage production and costume design.
De Tomasi collaborated with RAI (Italian Radio and Television) and directed the operatic content for the film on Giacomo Puccini by Sandro Bolchi. He was chosen by Francis Ford Coppola as the opera director for the production of Cavalleria rusticana in the film "The Godfather 3", produced by Zoetrope USA.
He wrote the libretto for "Il Ritratto di Dorian Gray" (Portrait of Dorian Gray) for Franco Mannino. He also prepared the winners of various competitions including "Aslico" of Milan, "Toti dal Monte" of Treviso, and the "Luciano Pavarotti" International Competition in 1993 in Philadelphia.
He is the teacher of stage production in Busseto, Orvieto and Bilbao.
His future engagements include: La Traviata in Istanbul, Un Ballo in maschera in Verona, Le Convenienze ed inconvenienze teatrali in Monte Carlo, Semiramide in Malaga, Lucia di Lammermoor in Bilbao, Il Viaggio a Reims in Lecce, Les Contes d'Hoffmann in Parma and many others.